The global community is negatively impacted on a large-scale with tens of millions of people worldwide suffering from major depression. Economic growth is being stunted and lifestyles and lives crippled. Unfortunately, it is not clear what the myriads of causative factors are. Is it stress alone or stress caused by medical or psychological disorders or unknown combinations of these and other factors? This new book tackles these issues head on by presenting the latest research findings in this pandemic. Trans-Cultural Studies; Investigating Major Depressive Disorders from an Evolutionary Theory Perspective: Fitness Hindrances and The Social Navigation Hypothesis; The Elaborated Cognitive Vulnerability-Transactional Stress Theory of Depression: Introduction of an Integrative General Model and Review of Evidence; Cardiomotor Circuitry, Angina, and Inflammation Mediators in Post-Myocardial Infarction Depression; Eating Disorders: Psycho-dynamic Approach and Therapeutic Attitudes; Cholesterol, Depression, and Suicidal Behaviour; Depression, and Pharmacological Treatments: Biologic Interactions; Antidepressants in the Acute Treatment of Adolescent Major Depression; A New Evaluation Scale for Depression Using a Verbal Information and a Multivariate Analysis; Index.