The fould Deviants, genetically unstable rivals of the Eternals, return once again, as the evil priestlord Ghaur attempts to assume the power of the Celestials. Can Ikaris and the Eternals, alongside the Earth's Mightiest Heroes, the Avengers, stop the mad deviant before it's too late? Next, across the Earth, teenage twins are being murdered, kicking off a prophecy that heralds the destruction of the race of Eternals. Plus, Neil Gaiman and Jon Romita Jr. herald the Eternals into the 21st century. Ike Harris dreams of adventures, love affairs and betrayals, but no one involved remembers or believes him. And who's trying to kill Harris to keep him from talking about it? Finally, Ikaris and the Eternals are dispatched to investigate strange goings on in Madripoor, only to discover a threat to all of humanity, including the Eternals.