This new book focuses on mathematical and numerical methods for medical images and data. The book presents the various mathematical modeling techniques, numerical analysis, computing and computational techniques, and applications of machine learning for medical images and medical informatics. It also focuses on programming concepts using MATLAB and Phython for medical image and signal analytics. The volume demonstrates the use of computational techniques and tools such as machine learning, deep neural networks, artificial intelligence and human-computer interaction ,fusion methods for CT and pet images, etc., for diagnosis of brain disorders, cervical cancer, lung disease, melanoma, atrial fibrillation and other circulatory issues, dental images, diabetes, and other medical issues.